Yes, sure. Our Advanced Permissions extension is highly customizable so that you can control an access to any area of your Magento as well as the types of the actions that can be performed by each admin role. Read on to make all the settings correctly.
Yes, you can make user's access denied, as well as create users with advanced roles/permissions. Define website/store view a sub-admin will have access to at the 'Advanced Permissions: Scope' with the following guide.